Δημοσιεύσεις

  1. Constantinides V.C., Koros C., Kyrozis A., Papathanasiou E., Manginas C., Arrmenis G., Kalligerou F., Daskalaki A., Koniari C., Ragazos N., Kontogeorgiou Z., Kartanou C., Linardaki E., Tavernarakis N., Karadima G., Koutsis G., Kapaki E., Scarmeas N., Stefanis L. and Papageorgiou S. (2026) Niemann Pick Type C Presenting as Familial Late-Onset Richardson Syndrome. A Case Series of Four Siblings Movement Disorders Clinical Practice, DOI: 10.1002/mdc3.70613

  2. Papadopoulou M-A., Chanoumidou K., Peteinareli M., Tsaglioti E., Michalaki K., Lavigne M.D. and Charalampopoulos I. (2026) p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer’s disease, Alzheimer’s Research and Therapy, DOI: 10.1186/s13195-026-01989-7

  3. Kefalogianni M., Mouchliadis L., Stratakis E. and Psilodimitrakopoulos S. (2026) Shell–Core Structural Anisotropy in Starch Granules Probed by Polarization Third-Harmonic Generation Microscopy. Photonics 13, 16, DOI: 10.3390/photonics13010016

  4. Tsagkari D., Markaki M. and Tavernarakis N. (2025) NHR-85 modulates mitochondrial and lipid homeostasis to protect against α-synuclein aggregation in C. elegans. Journal of Cell Science, 138: jcs263651.
  5. Mavroeidi P. and Xilouri M. (2025) Autophagy–Lysosome Pathway in Multiple System Atrophy Pathogenesis: The Best Is Yet to Come. Int. J. Mol. Sci., 26, 10204, DOI: 10.3390/ijms262010204
  6. Vekrellis K., Lamprokostopoulou A., Melachroinou K., Kokoli M., Zingkou E., Skarveli M., Kolianou A., Samiotaki M. and Sotiropoulou G. (2025) Proteolytic activities of extracellular vesicles attenuate A-synuclein aggregation. NPJ Parkinson’s Disease, 11:277, DOI: 10.1038/s41531-025-01122-9
  7. Fouka M., Tsakogias I., Gialinaki E.-G., Stavropoulos A., Volbracht C., De Muynck V., Moechars D., Melki R., Tofaris G.K., Stefanis L. and Xilouri M. (2025) In vivo validation of novel non-invasive PHP. eB AAVs as a potential therapeutic approach for alpha-synucleinopathies. Acta Neuropathologica Communications, 13:207, DOI: 10.1186/s40478-025-02121-w
  8. Papamatheakis D.A., Tzerpos P., Tsoukatou D., Morres E., Kapsetaki M., Balázs D., Igarashi K. and Spilianakis C. (2025), Genome organizer SATB1 restrains the BACH1- cMAF axis that drives autoimmunity, bioRxiv (preprint), DOI: 10.1101/2025.11.25.690242
  9. Paschou C., Apokotou O.,  Konstantina Charmpi K., and Papastefanaki F. (2025) Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson’s disease iPSC model, Neuroscience, 122 (47) e2505240122, DOI: 10.1073/pnas.2505240122
  10. Thanou I., Koutsoudaki P.N., Gorgoulis V.G., Margariti M., and Thomaidou D. (2025) Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion. Stem Cell Reports, Vol. 20, 102636, DOI: 10.1016/j.stemcr.2025.102636
  11. Margariti M., Thanou I., Papadimitriou E., Pelletier A., Xingi E., Kyrargyri V., Costa M.R. and Thomaidou D. (2025) Microglial BIN1 deficiency elicits enhanced microglial inflammatory responses that mimic early AD pathology, Research Square (preprint), DOI: 10.21203/rs.3.rs-7262443/v1
  12. Kaur A., Babaliari E., Bolanos-Garcia V.M., Kefalogianni M., Psilodimitrakopoulos S., Kavatzikidou P., Ranella A., Ghorbani M., Stratakis E., Eskin D.G. & Tzanakis I. (2025) Assessment of aqueous graphene as a cancer therapeutics delivery system. Scientific Reports, 15:15396, DOI: 10.1038/s41598-025-98406-0
  13. Tsagkari D., Panagiotidou E. and Tavernarakis N. (2025) The role of lipid metabolism in neuronal senescence. FEBS Open Bio, DOI: 10.1002/2211-5463.70181
  14. Kounakis K., Layana Castro P. E., Garcia Garvi A., Sanchez-Salmeron A.-J. and Tavernarakis N. (2025) Automated analysis of C. elegans fluorescence images using SegElegans. Journal of Visualized Experiments, 224: e69094.
  15. Georgoulakis M., Angelonidis I., Froudas K.G., Eleftheriadis N. and Neochoritis C.G. (2025) Privileged scaffolds on demand: a Passerini-based strategy toward α-ketoamides. Org. Biomol. Chem., DOI: 10.1039/d5ob01629k
  16. Somaraki M., Zachilas I., Tsapinou E., Boulkou G., Montagnon T., Vassilikogiannakis G. and Eleftheriadis N. (2025) Activating human 15-lipoxygenase-1 beyond flatland: discovery of non-aromatic modulators. Org. Biomol. Chem., DOI: 10.1039/d5ob00820d
  17. Adamis K.S., Georgoulakis M., Angelonidis I., Korovesis D., Papadopoulos C., Kapsalis M., Tavernarakis N., Eleftheriadis N. and G. Neochoritis C.G. (2025) The Evolution of Fluorescein into A Potential Theranostic Tool. Chem. Eur. J., 0, e202501513, DOI: 10.1002/chem.202501513
  18. Foukarakis I., Sampatakakis S, Mamalaki E., Kyrozis A., Ntanasi E., Tsapanou A., Yannakoulia M., Rouskas K. and Nikolaos Scarmeas N. (2025) Sleep architecture in Alzheimer’s disease continuum: The deep sleep question. Open Life Sciences; 20: 20251077, DOI: 10.1515/biol-2025-1077
  19. Bourboula A., Mantzourani C., Chalatsa I., Machalia C., Emmanouilidou E., Kokotou M.G. and Kokotos G. (2025) A Lipidomic Approach to Studying the Downregulation of Free Fatty Acids by Cytosolic Phospholipase A2 Inhibitors. Biomolecules, 15, 626, DOI: 10.3390/biom15050626
  20. Tsakiri E., Samiotaki M.,  Skoulakis E.M.C. and Papanikolopoulou K. (2025) Temporal Interactome Mapping of Human Tau in Drosophila Reveals Progressive Mitochondrial Engagement and Porin/VDAC1-Dependent Modulation of Toxicity Int. J. Mol. Sci., 26, 9741, DOI: 10.3390/ijms26199741
  21. Santambrogio A.,  Horne R.I., Metrick M.A., Gallagher N.C.T.,  Brotzakis F., Rinauro D., Vourkou E.,  Papanikolopoulou K.,  Skoulakis E.M.C., Linse S., Caughey B., and Vendruscolo M. (2025) Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay, J. Am. Chem. Soc., 147 (39), 35942−35952. DOI: 10.1021/jacs.5c12812
  22. Ai R., Mao L., Jin X., Campos-Marques C., Zhang S., Pan J., Lagartos-Donate M.J., Cao S.-Q.,  Barros-Santos B.,  Nobrega-Martins R., Katsaitis F., Yang G., Xie C., Kang X., Wang P., Novello M., Hu Y., Bergersen L.H., Storm-Mathisen J., Kuroyanagi H., Escobar-Doncel B., Villaseca Gonzαlez N.,  Chaudhry F.A., Wang Z., Zhang Q., Lu G., Sotiropoulos I., Niu Z., Chen G., Nair R.R., Silva J.M., Luo O.J. and Fang E.F. (2025) NAD+ reverses Alzheimer’s neurological deficits via regulating differential alternative RNA splicing of EVA1C Sci. Adv. 11 (45), eady9811. DOI: 10.1126/sciadv.ady9811
  23. Koros C., Simitsi A.-M., Papagiannakis N., Antonelou R., Bougea A., Papadimitriou D., Pachi I., Beratis I., Kontaxopoulou D., Fragkiadaki S., Sfikas E., Alefanti I., Chrysovitsanou C., Angelopoulou E., Bregianni M., Lourentzos K., Constantinides V.C., Velonakis G., Prassopoulos V., Bonakis A., Papageorgiou S.G., Potagas C., Picillo M., Barone P., Stamelou M. and Stefanis L. (2025) Peripheral Immune pattern in a genetic cohort of p.A53T alpha-synuclein carriers. Parkinsonism and Related Disorders, 135, 107853, DOI: 10.1016/j.parkreldis.2025.107853
  24. Grammenos G., Vrahatis A.G., Lazaros K., Exarchos T.P., Vlamos P. and Krokidis M.G. (2025) AI agents in Altzheimer’s disease management: challenges and future directions. Frontiers in Aging Neuroscience, 17:1735892 DOI: 10.3389/fnagi.2025.1735892
  25. Krokidis M.G., Koumadorakis D.E., Lazaros K., Ivantsik O., Exarchos T.P., Vrahatis A.G., Kotsiantis S. and Vlamos P. (2025) AlphaFold3: An Overview of Applications and Performance Insights. Int. J. Mol. Sci., 26, 3671, DOI: 10.3390/ijms26083671
  26. Lazaros K., Adam S., Krokidis M.G., Exarchos T., Vlamos P. and Vrahatis A.G. (2025) Non-Invasive Biomarkers in the Era of Big Data and Machine Learning. Sensors, 25, 1396, DOI: 10.3390/s25051396
  27. Statoulla E., Zafeiri M. Chalkiadaki K., Voudouri G., Gkika K.S., Papazoglou C., Durcan T., Khoutorsky A., Mehdi Jafarnejad S., Sarah Maguire S., Alexander Dityatev A. and. Gkogkas C.G (2025) SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids. bioRxiv (preprint), DOI: 10.1101/2025.05.28.656641
  28. Liakakis G., Vakrakou A.G., Boufidou F., Constantinides V., Velonakis G., Paraskevas G.P., Stefanis L. and Kapaki E. (2025) Exploratory Analysis of Cerebrospinal Fluid IL-6 and IL-17A Levels in Subcortical Small-Vessel Disease Compared to Alzheimer’s Disease: A Pilot Study. Diagnostics, 15, 669, DOI: 10.3390/diagnostics15060669
  29. Dimoula K., Papagiannakis N., Maniati M., Stefanis L. and Emmanouilidou E. (2025) Aggregated α-synuclein in erythrocytes as a potential biomarker for idiopathic Parkinson’s Disease. Parkinsonism and Related Disorders, 133, 107321, DOI: 10.1016/j.parkreldis.2025.107321
  30. Kartanou C., Kontogeorgiou Z., Loupis T., Vrachnos D.M., Ragazos N., Spyropoulou I., Petraki M., Koniari C., Aristeidou S., Koropouli E., Daponte A., Rentzos M., Kapaki E., Panas M., Makrythanasis P., Stefanis L., Koutsis G. and Karadima G. (2025) Unraveling the genetic landscape of ALS in Greece: identification of known and novel causative variants in a 353-patient cohort. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 0: 1–10 DOI: 10.1080/21678421.2025.2582828
  31. Lazaros K., Krokidis M.G., Grammenos G, Adam S., Exarchos T.P., Vlamos P. and Vrahatis A.G. (2025) Uncovering Molecular Insights into Blood–Brain Barrier Dysfunction in Alzheimer’s Disease. 2025 IEEE 25th International Conference on Bioinformatics and Bioengineering (BIBE), DOI: 10.1109/BIBE66822.2025.00013
  32. Papikinos T., Krokidis M., Vrahatis A., Vlamos P. and Exarchos T. (2025) Investigating protein folding as a target for neurodegenerative disorders using a biological activity prediction model based on deep learning. ICCBIKG, DOI: 10.46793/ICCBIKG25.319P
  33. Papatheodorou M.C. P., Exarchos T.P., Vlamos P.M., Krokidis M.G. (2025) Effect of Amyloid-beta Exposure on Phospholipid Dynamics: A Computational and Cellular Perspective. ICCBIKG, DOI: 10.46793/ICCBIKG25.331P
  34. Kokkali M., Karali K., Thanou E., Maria Anna Papadopoulou M.A., Zota I., Tsimpolis A., Efstathopoulos P., Calogeropoulou T., Li K.W., Sidiropoulou K., Gravanis A. and Charalampopoulos I. (2024) Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s disease. Molecular Psychiatry, 30:2265–2283; DOI: 10.1038/s41380-024-02833-w
  35. Papadopoulou M-A., Chanoumidou K., Peteinareli M., Tsaglioti E., Michalaki K., Lavigne M.D. and Charalampopoulos I. (2025) p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer’s disease, bioRxiv preprint, DOI: 10.1101/2025.09.11.675537
  36. Zaganas I., Tsiverdis I., Kokosali E., Litso I., Drakos M., Skoula I., Zabetakis A., Mathioudakis L., Mastorodemos V. and Mitsias P. (2025) Study of the NOTCH3 Gene Reveals the First CADASIL Cases in Crete and a Novel Pathogenic Variant. Brain and Behavior, 15:e70789, DOI: 10.1002/brb3.70789
  37. Louka A., Spacho N., Korovesis D., Adamis K., Papadopoulos C., Kalaitzaki E.-E., Tavernarakis N., Neochoritis C.G. and Eleftheriadis N. (2025) Crafting Molecular Tools for 15-Lipoxygenase-1 in a Single Step. Angewandte Chemie, 64: e202418291
  38. Karavasilis E., Balomenos V., Christidi F., Velonakis G., Angelopoulou G., Yannakoulia M., Mamalaki E., Drouka A., Brikou D., Tsapanou A., Gu Y. and Scarmeas N. (2024) Mediterranean diet and brain functional connectivity in a population without dementia. Frontiers in Neuroimaging, DOI: 10.3389/fnimg.2024.1473399
  39. Alefanti I., Koros C., Tsami V., Simitsi A.-M., Chrisoula Kartanou C., Papagiannakis N., Bozi M., Antonelou R., Maniati M., Hauser A.-K., Varvaressos S., Bonakis A., Lourentzos K., Makrythanasis P., Papageorgiou S.G., Proukakis C., Potagas C., Gasser T., Koutsis G., Karadima G. and Stefanis L (2024) The novel p.A30G SNCA pathogenic variant in Greek patients with familial and sporadic Parkinson's disease. Eur J Neurol.;32: e16562, DOI: 10.1111/ene.16562
  40. Theodoropoulou M.A., Mantzourani C. and Kokotos G. (2024) Histone Deacetylase (HDAC) Inhibitors as a Novel Therapeutic Option Against Fibrotic and Inflammatory Diseases, Biomolecules, 14, 1605. DOI:10.3390/biom14121605

  41. Arvanitaki E., Goulielmaki E., Gkirtzimanaki K., Niotis G., Tsakani E., Nenedaki E., Rouska I., Kefalogianni M., Xydias D., Kalafatakis I., Psilodimitrakopoulos S., Karagogeos D., Schumacher B., Stratakis M. and Garinis G. (2024) Microglia-derived extracellular vesicles trigger age-related neurodegeneration upon DNA damage, PNAs, DOI: 10.1073/pnas.2317402121 

  42. Stavgiannoudaki I., Goulielmaki E. and Garinis G. (2024) Broken strands, broken minds: Exploring the nexus of DNA damage and neurodegeneration. DNA repair, DOI: 10.1016/j.dnarep.2024.103

  43. Tiwari V., Buvarp E., Borbolis F., Puligilla C., Croteau D.L., Palikaras K. and Bohr V.A. (2024) Loss of DNA glycosylases improves health and cognitive function in a C. elegans model of human tauopathy. Nucleic Acids Research, 52, 10965–10985, DOI:10.1093/nar/gkae705
  44. Vekrellis K., Emmanouilidou E., Xilouri M. and Stefanis L. (2024) α-Synuclein in Parkinson’s Disease: 12 Years Later. Cold Spring Harb Perspect Med, DOI: 10.1101/cshperspect.a041645
  45. Christidi F., Drouka A., Brikou D., Mamalaki E., Ntanasi E., Karavasilis E., Velonakis G., Angelopoulou G., Tsapanou A., Gu Y., Yannakoulia M.and Scarmeas N. (2024) The Association between Individual Food Groups, Limbic System White Matter Tracts, and Episodic Memory: Initial Data from the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration (ALBION) Study. Nutrients, 16, 2766, DOI: 10.3390/nu16162766
  46. Spacho N., Casertano M., Imperatore C., Papadopoulos C., Menna M. and Eleftheriadis N. (2024) Investigating the Catalytic Site of Human 15-Lipoxygenase- 1 via Marine Natural Products. Chem. Eur. J. e202402279, DOI: 10.1002/chem.202402279
  47. Giotas E., Kaplani S.-A. and Eleftheriadis N. (2024) The Multifunctional Preprotein Binding Domain of SecA.  ChemBioChem, e202400621, DOI: 10.1002/cbic.202400621
  48. Chalkiadaki K., Statoulla E., Zafeiri M., Voudouri G., Amvrosiadis T., Typou A., Theodoridou N., Moschovas D., Avgeropoulos A., Samiotaki M., Mason J.O. and Gkogkas C.G. (2024) GABA/Glutamate Neuron Differentiation Imbalance and Increased AKT/mTOR Signaling in CNTNAP22/2 Cerebral Organoids. Biol Psychiatry Glob Open Sci., DOI: 10.1016/j.bpsgos.2024.100413
  49. Tsare E.-P.G., Klapa M.I. and Moschonas N.K. (2024) Investigating differences in the GWAS-based protein-protein interaction network of blood pressure regulation due to ancestry or transcript consequence severity, Proceedings of the 10th IFAC Conference on Foundations of Systems Biology in Engineering, Corfu Island, Greece, September 8-11, 2024
  50. Barmpa K., Saraiva C., Lopez-Pigozzi D., Gomez-Giro G., Gabassi E., Spitz S., Brandauer K., Rodriguez Gatica J.E., Antony P., Robertson G., Sabahi-Kaviani R., Bellapianta A., Papastefanaki F., Luttge R., Kubitscheck U., Salti A., Ertl P., Bortolozzi M., Matsas R., Edenhofer F. and Schwamborn J.C. (2024) Modeling early phenotypes of Parkinson’s disease by age-induced midbrainstriatum assembloids, Communications Biology, 7:1561, DOI: 10.1038/s42003-024-07273-4
  51. Kokkorakis  N.,  Zouridakis M. and Gaitanou M. (2024) Mirk/Dyrk1B Kinase Inhibitors in Targeted Cancer Therapy. Pharmaceutics 11;16(4):528, DOI: 10.3390/pharmaceutics16040528.
  52. Lazaros K., Gonidi M., Kontara N., Krokidis M.G., Vrahatis A.G., Exarchos T. and Vlamos P. (2024) Exploring the Association between Pro-Inflammation and the Early Diagnosis of Alzheimer’s Disease in Buccal Cells Using Immunocytochemistry and Machine Learning Techniques. Appl. Sci., 14, 8372, DOI: 10.3390/app14188372
  53. Giannakis A., Vartholomatos E., Astrakas L., Anyfantis E., Tatsioni A., Argyropoulou M. and Konitsiotis S. (2024) An SBM and TBSS Analysis in Early-stage Patients With Alzheimer’s Disease, Lewy Body Dementias, and Corticobasal Syndrome. Journal of Geriatric Psychiatry and Neurology, 0(0) 1–11, DOI: 10.1177/08919887241302110
  54. Karanikolaos P., Krokidis M.G., Exarchos T.P. and Vlamos P. (2024) Computational Analysis of Marker Genes in Alzheimer’s Disease across Multiple Brain Regions. Information, 15, 523, DOI: 10.3390/info15090523
  55. Ktena N., Spyridakos D., Georgilis A., Kalafatakis I., Efstathia Thomoglou E., Kolaxi A., Nikoletopoulou V., Savvaki M. and Karagogeos D. (2025) Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice. Glia, 0:1–15, DOI: 10.1002/glia.70012
  56. Exarchos T., Dimakopoulos G.A., Lazaros K., Krokidis M., Vrahatis A., Grammenos G., Avramouli A., Skolariki K., Adams R., Mahairaki V., Oh E.S., Leoutsakos J., Rosenberg P.B., Lyketsos C.G. and Vlamos P. (2025) Five-year dementia prediction and decision support system based on real-world data. Frontiers in Aging Neuroscience, 17, DOI: 10.3389/fnagi.2025.1670609
  57. Perperidis K., Exarchos T.P., Vrahatis A.G., Vlamos P. and Krokidis M.G. (2025) Computational analysis of transcriptome data and mapping of functional networks in Parkinson’s disease, Frontiers in Bioinformatics, 5, DOI: 10.3389/fbinf.2025.1690229
  58. Exarchos T.P., Skolariki K., Mahairaki V., Lyketsos C.G., Vlamos P., Scarmeas N., Dardiotis E. and on behalf of the Hellenic Initiative Against Alzheimer’s Disease (HIAAD) (2025) Geographic Distribution and Future Projections of Mild Cognitive Impairment and Dementia in Greece: Analysis from 1991 to 2050. Brain Sciences, 15, 661, DOI: 10.3390/brainsci15060661

ΣχετικΑ

«Εμβληματικές δράσεις σε διαθεματικές επιστημονικές περιοχές με ειδικό ενδιαφέρον για την σύνδεση με τον παραγωγικό ιστό» 

Κωδικός Αίτησης: TAEDR-0535850
Η δράση υλοποιείται στο πλαίσιο του Εθνικού Σχεδίου Ανάκαμψης και Ανθεκτικότητας Ελλάδα 2.0 «Με τη Χρηματοδότηση της Ευρωπαϊκής Ένωσης – NextGenerationEU» 

ΣΥΝΔΕΣΜΟΙ

Image


ΓΕΝΙΚΗ ΓΡΑΜΜΑΤΕΙΑ ΕΡΕΥΝΑΣ ΚΑΙ ΚΑΙΝΟΤΟΜΙΑΣ

ΥΠΟΥΡΓΕΙΟ ΑΝΑΠΤΥΞΗΣ

«Εμβληματικές δράσεις σε διαθεματικές επιστημονικές περιοχές με ειδικό ενδιαφέρον για την σύνδεση με τον παραγωγικό ιστό»
Ανάδειξη, επιβεβαίωση και αξιοποίηση της γενετικής βάσης μη-μεταδοτικών πολυπαραγοντικών νοσημάτων για την ανάπτυξη νέων θεραπευτικών προσεγγίσεων και αξιόπιστων βιοδεικτών
Φορέας Υλοποίησης Υπουργείο Οικονομικών,
Ειδική Υπηρεσία Συντονισμού Ταμείου Ανάκαμψης