Δημοσιεύσεις

  1. Kefalogianni M., Mouchliadis L., Stratakis E. and Psilodimitrakopoulos S. (2026) Shell–Core Structural Anisotropy in Starch Granules Probed by Polarization Third-Harmonic Generation Microscopy. Photonics 13, 16, DOI: 10.3390/photonics13010016
  2. Tsagkari D., Markaki M. and Tavernarakis N. (2025) NHR-85 modulates mitochondrial and lipid homeostasis to protect against α-synuclein aggregation in C. elegans. Journal of Cell Science, 138: jcs263651.
  3. Mavroeidi P. and Xilouri M. (2025) Autophagy–Lysosome Pathway in Multiple System Atrophy Pathogenesis: The Best Is Yet to Come. Int. J. Mol. Sci., 26, 10204, DOI: 10.3390/ijms262010204
  4. Vekrellis K., Lamprokostopoulou A., Melachroinou K., Kokoli M., Zingkou E., Skarveli M., Kolianou A., Samiotaki M. and Sotiropoulou G. (2025) Proteolytic activities of extracellular vesicles attenuate A-synuclein aggregation. NPJ Parkinson’s Disease, 11:277, DOI: 10.1038/s41531-025-01122-9
  5. Fouka M., Tsakogias I., Gialinaki E.-G., Stavropoulos A., Volbracht C., De Muynck V., Moechars D., Melki R., Tofaris G.K., Stefanis L. and Xilouri M. (2025) In vivo validation of novel non-invasive PHP. eB AAVs as a potential therapeutic approach for alpha-synucleinopathies. Acta Neuropathologica Communications, 13:207, DOI: 10.1186/s40478-025-02121-w
  6. Papamatheakis D.A., Tzerpos P., Tsoukatou D., Morres E., Kapsetaki M., Balázs D., Igarashi K. and Spilianakis C. (2025), Genome organizer SATB1 restrains the BACH1- cMAF axis that drives autoimmunity, bioRxiv (preprint), DOI: 10.1101/2025.11.25.690242
  7. Paschou C., Apokotou O.,  Konstantina Charmpi K., and Papastefanaki F. (2025) Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson’s disease iPSC model, Neuroscience, 122 (47) e2505240122, DOI: 10.1073/pnas.2505240122
  8. Thanou I., Koutsoudaki P.N., Gorgoulis V.G., Margariti M., and Thomaidou D. (2025) Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion. Stem Cell Reports, Vol. 20, 102636, DOI: 10.1016/j.stemcr.2025.102636
  9. Margariti M., Thanou I., Papadimitriou E., Pelletier A., Xingi E., Kyrargyri V., Costa M.R. and Thomaidou D. (2025) Microglial BIN1 deficiency elicits enhanced microglial inflammatory responses that mimic early AD pathology, Research Square (preprint), DOI: 10.21203/rs.3.rs-7262443/v1
  10. Kaur A., Babaliari E., Bolanos-Garcia V.M., Kefalogianni M., Psilodimitrakopoulos S., Kavatzikidou P., Ranella A., Ghorbani M., Stratakis E., Eskin D.G. & Tzanakis I. (2025) Assessment of aqueous graphene as a cancer therapeutics delivery system. Scientific Reports, 15:15396, DOI: 10.1038/s41598-025-98406-0
  11. Tsagkari D., Panagiotidou E. and Tavernarakis N. (2025) The role of lipid metabolism in neuronal senescence. FEBS Open Bio, DOI: 10.1002/2211-5463.70181
  12. Kounakis K., Layana Castro P. E., Garcia Garvi A., Sanchez-Salmeron A.-J. and Tavernarakis N. (2025) Automated analysis of C. elegans fluorescence images using SegElegans. Journal of Visualized Experiments, 224: e69094.
  13. Georgoulakis M., Angelonidis I., Froudas K.G., Eleftheriadis N. and Neochoritis C.G. (2025) Privileged scaffolds on demand: a Passerini-based strategy toward α-ketoamides. Org. Biomol. Chem., DOI: 10.1039/d5ob01629k
  14. Somaraki M., Zachilas I., Tsapinou E., Boulkou G., Montagnon T., Vassilikogiannakis G. and Eleftheriadis N. (2025) Activating human 15-lipoxygenase-1 beyond flatland: discovery of non-aromatic modulators. Org. Biomol. Chem., DOI: 10.1039/d5ob00820d
  15. Adamis K.S., Georgoulakis M., Angelonidis I., Korovesis D., Papadopoulos C., Kapsalis M., Tavernarakis N., Eleftheriadis N. and G. Neochoritis C.G. (2025) The Evolution of Fluorescein into A Potential Theranostic Tool. Chem. Eur. J., 0, e202501513, DOI: 10.1002/chem.202501513
  16. Foukarakis I., Sampatakakis S, Mamalaki E., Kyrozis A., Ntanasi E., Tsapanou A., Yannakoulia M., Rouskas K. and Nikolaos Scarmeas N. (2025) Sleep architecture in Alzheimer’s disease continuum: The deep sleep question. Open Life Sciences; 20: 20251077, DOI: 10.1515/biol-2025-1077
  17. Bourboula A., Mantzourani C., Chalatsa I., Machalia C., Emmanouilidou E., Kokotou M.G. and Kokotos G. (2025) A Lipidomic Approach to Studying the Downregulation of Free Fatty Acids by Cytosolic Phospholipase A2 Inhibitors. Biomolecules, 15, 626, DOI: 10.3390/biom15050626
  18. Koros C., Simitsi A.-M., Papagiannakis N., Antonelou R., Bougea A., Papadimitriou D., Pachi I., Beratis I., Kontaxopoulou D., Fragkiadaki S., Sfikas E., Alefanti I., Chrysovitsanou C., Angelopoulou E., Bregianni M., Lourentzos K., Constantinides V.C., Velonakis G., Prassopoulos V., Bonakis A., Papageorgiou S.G., Potagas C., Picillo M., Barone P., Stamelou M. and Stefanis L. (2025) Peripheral Immune pattern in a genetic cohort of p.A53T alpha-synuclein carriers. Parkinsonism and Related Disorders, 135, 107853, DOI: 10.1016/j.parkreldis.2025.107853
  19. Grammenos G., Vrahatis A.G., Lazaros K., Exarchos T.P., Vlamos P. and Krokidis M.G. (2025) AI agents in Altzheimer’s disease management: challenges and future directions. Frontiers in Aging Neuroscience, 17:1735892 DOI: 10.3389/fnagi.2025.1735892
  20. Krokidis M.G., Koumadorakis D.E., Lazaros K., Ivantsik O., Exarchos T.P., Vrahatis A.G., Kotsiantis S. and Vlamos P. (2025) AlphaFold3: An Overview of Applications and Performance Insights. Int. J. Mol. Sci., 26, 3671, DOI: 10.3390/ijms26083671
  21. Lazaros K., Adam S., Krokidis M.G., Exarchos T., Vlamos P. and Vrahatis A.G. (2025) Non-Invasive Biomarkers in the Era of Big Data and Machine Learning. Sensors, 25, 1396, DOI: 10.3390/s25051396
  22. Statoulla E., Zafeiri M. Chalkiadaki K., Voudouri G., Gkika K.S., Papazoglou C., Durcan T., Khoutorsky A., Mehdi Jafarnejad S., Sarah Maguire S., Alexander Dityatev A. and. Gkogkas C.G (2025) SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids. bioRxiv (preprint), DOI: 10.1101/2025.05.28.656641
  23. Liakakis G., Vakrakou A.G., Boufidou F., Constantinides V., Velonakis G., Paraskevas G.P., Stefanis L. and Kapaki E. (2025) Exploratory Analysis of Cerebrospinal Fluid IL-6 and IL-17A Levels in Subcortical Small-Vessel Disease Compared to Alzheimer’s Disease: A Pilot Study. Diagnostics, 15, 669, DOI: 10.3390/diagnostics15060669
  24. Dimoula K., Papagiannakis N., Maniati M., Stefanis L. and Emmanouilidou E. (2025) Aggregated α-synuclein in erythrocytes as a potential biomarker for idiopathic Parkinson’s Disease. Parkinsonism and Related Disorders, 133, 107321, DOI: 10.1016/j.parkreldis.2025.107321
  25. Louka A., Spacho N., Korovesis D., Adamis K., Papadopoulos C., Kalaitzaki E.-E., Tavernarakis N., Neochoritis C.G. and Eleftheriadis N. (2025) Crafting Molecular Tools for 15-Lipoxygenase-1 in a Single Step. Angewandte Chemie, 64: e202418291
  26. Karavasilis E., Balomenos V., Christidi F., Velonakis G., Angelopoulou G., Yannakoulia M., Mamalaki E., Drouka A., Brikou D., Tsapanou A., Gu Y. and Scarmeas N. (2024) Mediterranean diet and brain functional connectivity in a population without dementia. Frontiers in Neuroimaging, DOI: 10.3389/fnimg.2024.1473399
  27. Alefanti I., Koros C., Tsami V., Simitsi A.-M., Chrisoula Kartanou C., Papagiannakis N., Bozi M., Antonelou R., Maniati M., Hauser A.-K., Varvaressos S., Bonakis A., Lourentzos K., Makrythanasis P., Papageorgiou S.G., Proukakis C., Potagas C., Gasser T., Koutsis G., Karadima G. and Stefanis L (2024) The novel p.A30G SNCA pathogenic variant in Greek patients with familial and sporadic Parkinson's disease. Eur J Neurol.;32: e16562, DOI: 10.1111/ene.16562
  28. Theodoropoulou M.A., Mantzourani C. and Kokotos G. (2024) Histone Deacetylase (HDAC) Inhibitors as a Novel Therapeutic Option Against Fibrotic and Inflammatory Diseases, Biomolecules, 14, 1605. DOI:10.3390/biom14121605
  29. Tiwari V., Buvarp E., Borbolis F., Puligilla C., Croteau D.L., Palikaras K. and Bohr V.A. (2024) Loss of DNA glycosylases improves health and cognitive function in a C. elegans model of human tauopathy. Nucleic Acids Research, 52, 10965–10985, DOI:10.1093/nar/gkae705
  30. Vekrellis K., Emmanouilidou E., Xilouri M. and Stefanis L. (2024) α-Synuclein in Parkinson’s Disease: 12 Years Later. Cold Spring Harb Perspect Med, DOI: 10.1101/cshperspect.a041645
  31. Christidi F., Drouka A., Brikou D., Mamalaki E., Ntanasi E., Karavasilis E., Velonakis G., Angelopoulou G., Tsapanou A., Gu Y., Yannakoulia M.and Scarmeas N. (2024) The Association between Individual Food Groups, Limbic System White Matter Tracts, and Episodic Memory: Initial Data from the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration (ALBION) Study. Nutrients, 16, 2766, DOI: 10.3390/nu16162766
  32. Spacho N., Casertano M., Imperatore C., Papadopoulos C., Menna M. and Eleftheriadis N. (2024) Investigating the Catalytic Site of Human 15-Lipoxygenase- 1 via Marine Natural Products. Chem. Eur. J. e202402279, DOI: 10.1002/chem.202402279
  33. Giotas E., Kaplani S.-A. and Eleftheriadis N. (2024) The Multifunctional Preprotein Binding Domain of SecA.  ChemBioChem, e202400621, DOI: 10.1002/cbic.202400621
  34. Chalkiadaki K., Statoulla E., Zafeiri M., Voudouri G., Amvrosiadis T., Typou A., Theodoridou N., Moschovas D., Avgeropoulos A., Samiotaki M., Mason J.O. and Gkogkas C.G. (2024) GABA/Glutamate Neuron Differentiation Imbalance and Increased AKT/mTOR Signaling in CNTNAP22/2 Cerebral Organoids. Biol Psychiatry Glob Open Sci., DOI: 10.1016/j.bpsgos.2024.100413
  35. Tsare E.-P.G., Klapa M.I. and Moschonas N.K. (2024) Investigating differences in the GWAS-based protein-protein interaction network of blood pressure regulation due to ancestry or transcript consequence severity, Proceedings of the 10th IFAC Conference on Foundations of Systems Biology in Engineering, Corfu Island, Greece, September 8-11, 2024
  36. Barmpa K., Saraiva C., Lopez-Pigozzi D., Gomez-Giro G., Gabassi E., Spitz S., Brandauer K., Rodriguez Gatica J.E., Antony P., Robertson G., Sabahi-Kaviani R., Bellapianta A., Papastefanaki F., Luttge R., Kubitscheck U., Salti A., Ertl P., Bortolozzi M., Matsas R., Edenhofer F. and Schwamborn J.C. (2024) Modeling early phenotypes of Parkinson’s disease by age-induced midbrainstriatum assembloids, Communications Biology, 7:1561, DOI: 10.1038/s42003-024-07273-4
  37. Kokkorakis  N.,  Zouridakis M. and Gaitanou M. (2024) Mirk/Dyrk1B Kinase Inhibitors in Targeted Cancer Therapy. Pharmaceutics 11;16(4):528, DOI: 10.3390/pharmaceutics16040528.
  38. Lazaros K., Gonidi M., Kontara N., Krokidis M.G., Vrahatis A.G., Exarchos T. and Vlamos P. (2024) Exploring the Association between Pro-Inflammation and the Early Diagnosis of Alzheimer’s Disease in Buccal Cells Using Immunocytochemistry and Machine Learning Techniques. Appl. Sci., 14, 8372, DOI: 10.3390/app14188372
  39. Giannakis A., Vartholomatos E., Astrakas L., Anyfantis E., Tatsioni A., Argyropoulou M. and Konitsiotis S. (2024) An SBM and TBSS Analysis in Early-stage Patients With Alzheimer’s Disease, Lewy Body Dementias, and Corticobasal Syndrome. Journal of Geriatric Psychiatry and Neurology, 0(0) 1–11, DOI: 10.1177/08919887241302110
  40. Karanikolaos P., Krokidis M.G., Exarchos T.P. and Vlamos P. (2024) Computational Analysis of Marker Genes in Alzheimer’s Disease across Multiple Brain Regions. Information, 15, 523, DOI: 10.3390/info15090523
  41. Ktena N., Spyridakos D., Georgilis A., Kalafatakis I., Efstathia Thomoglou E., Kolaxi A., Nikoletopoulou V., Savvaki M. and Karagogeos D. (2025) Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice. Glia, 0:1–15, DOI: 10.1002/glia.70012
  42. Exarchos T., Dimakopoulos G.A., Lazaros K., Krokidis M., Vrahatis A., Grammenos G., Avramouli A., Skolariki K., Adams R., Mahairaki V., Oh E.S., Leoutsakos J., Rosenberg P.B., Lyketsos C.G. and Vlamos P. (2025) Five-year dementia prediction and decision support system based on real-world data. Frontiers in Aging Neuroscience, 17, DOI: 10.3389/fnagi.2025.1670609
  43. Perperidis K., Exarchos T.P., Vrahatis A.G., Vlamos P. and Krokidis M.G. (2025) Computational analysis of transcriptome data and mapping of functional networks in Parkinson’s disease, Frontiers in Bioinformatics, 5, DOI: 10.3389/fbinf.2025.1690229
  44. Exarchos T.P., Skolariki K., Mahairaki V., Lyketsos C.G., Vlamos P., Scarmeas N., Dardiotis E. and on behalf of the Hellenic Initiative Against Alzheimer’s Disease (HIAAD) (2025) Geographic Distribution and Future Projections of Mild Cognitive Impairment and Dementia in Greece: Analysis from 1991 to 2050. Brain Sciences, 15, 661, DOI: 10.3390/brainsci15060661

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«Εμβληματικές δράσεις σε διαθεματικές επιστημονικές περιοχές με ειδικό ενδιαφέρον για την σύνδεση με τον παραγωγικό ιστό» 

Κωδικός Αίτησης: TAEDR-0535850
Η δράση υλοποιείται στο πλαίσιο του Εθνικού Σχεδίου Ανάκαμψης και Ανθεκτικότητας Ελλάδα 2.0 «Με τη Χρηματοδότηση της Ευρωπαϊκής Ένωσης – NextGenerationEU» 

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ΓΕΝΙΚΗ ΓΡΑΜΜΑΤΕΙΑ ΕΡΕΥΝΑΣ ΚΑΙ ΚΑΙΝΟΤΟΜΙΑΣ

ΥΠΟΥΡΓΕΙΟ ΑΝΑΠΤΥΞΗΣ

«Εμβληματικές δράσεις σε διαθεματικές επιστημονικές περιοχές με ειδικό ενδιαφέρον για την σύνδεση με τον παραγωγικό ιστό»
Ανάδειξη, επιβεβαίωση και αξιοποίηση της γενετικής βάσης μη-μεταδοτικών πολυπαραγοντικών νοσημάτων για την ανάπτυξη νέων θεραπευτικών προσεγγίσεων και αξιόπιστων βιοδεικτών
Φορέας Υλοποίησης Υπουργείο Οικονομικών,
Ειδική Υπηρεσία Συντονισμού Ταμείου Ανάκαμψης